The Khorana score is used to estimate the probability, for cancer patients treated with chemotherapy, of developing an episode of VTE. It is based on five clinical and biological variables:
1) The type of Cancer
2) A platelet count ≥ 350 x 109/L
3) Hemoglobin < 10g/dL and/or use of erythropoiesis-stimulating agents
4) A white blood cell count > 11 x 109/L
5) A body mass index (BMI) ≥ 35 Kg/m2
The diagnostic performance of the Khorana score has been validated in numerous external validation cohorts. Its relevance remains debated for certain types of cancer.
Thromboembolic disease is a common disease of the veins that affects approximately one in a thousand people in the population. Characterized by the occlusion or narrowing of a vein by a blood clot, it manifests as thrombosis (clot in a vein) or pulmonary embolism (clot in an artery of the lungs).
Deep vein thrombosis (DVT) is characterized by the presence of a blood clot completely or partially blocking blood flow in a deep vein. It can occur in any deep vein in the body but is more common in the lower limbs.
DVT is manifested by pain, with or without swelling (edema), of the affected limb. This condition requires an emergency diagnosis by Medical ultrasound examination and must be treated immediately. If not detected and treated quickly, a fragment of blood clot can travel to the lung and lead to a potentially fatal pulmonary embolism.
Superficial vein thrombosis (SVT) is characterized by the presence of a blood clot completely or partially blocking blood flow in a superficial vein. It can occur in any superficial vein of the body, but it is more common in the lower and upper limbs.
SVT is manifested by pain, with or without swelling, of the affected limb. Although generally a milder condition than DVT, it still requires diagnosis by ultrasound Doppler examination